Use of (1)H NMR to facilitate solubility measurement for drug discovery compounds.
نویسندگان
چکیده
The use of (1)H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies.
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عنوان ژورنال:
- International journal of pharmaceutics
دوره 369 1-2 شماره
صفحات -
تاریخ انتشار 2009